Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF by single substrate depletion
نویسندگان
چکیده
Naama Kanarek, Elad Horwitz, Inbal Mayan, Michael Leshets, Gady Cojocaru, Matti Davis, Ben-Zion Tsuberi, Eli Pikarsky, Michele Pagano, and Yinon Ben-Neriah The Lautenberg Center for Immunology, Jerusalem 91120, Israel; Department of Pathology, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel; Department of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, New York 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, New York 10016, USA
منابع مشابه
Occurrence of a putative SCF ubiquitin ligase complex in Drosophila.
Many proteins are targeted to proteasome degradation by a family of E3 ubiquitin ligases, termed SCF complexes, that link substrate proteins to an E2 ubiquitin-conjugating enzyme. SCFs are composed of three core proteins-Skp1, Cdc53/Cull, Rbx1/Hrt1-and a substrate specific F-box protein. We have identified in Drosophila melanogaster the closest homologues to the human components of the SCF(beta...
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